Biosynthesis of the thiamin thiazole in Bacillus subtilis: identification of the product of the thiazole synthase-catalyzed reaction. Academic Article uri icon


  • In this paper, we describe an optimized reconstitution of the thiamin thiazole synthase (ThiG) catalyzed reaction and demonstrate that the enzymatic product is an unanticipated dearomatized thiazole tautomer.

published proceedings

  • J Am Chem Soc

altmetric score

  • 3

author list (cited authors)

  • Hazra, A., Chatterjee, A., & Begley, T. P.

citation count

  • 20

complete list of authors

  • Hazra, Amrita||Chatterjee, Abhishek||Begley, Tadhg P

publication date

  • February 2009