Biosynthesis of the thiamin thiazole in Bacillus subtilis: identification of the product of the thiazole synthase-catalyzed reaction. Academic Article

abstract

• In this paper, we describe an optimized reconstitution of the thiamin thiazole synthase (ThiG) catalyzed reaction and demonstrate that the enzymatic product is an unanticipated dearomatized thiazole tautomer.

authors

• Begley, Tadhg

published proceedings

• J Am Chem Soc

altmetric score

• 3

author list (cited authors)

• Hazra, A., Chatterjee, A., & Begley, T. P.

citation count

• 20

complete list of authors

• Hazra, Amrita||Chatterjee, Abhishek||Begley, Tadhg P

publication date

• March 2009

publisher

• American Chemical Society (ACS)  Publisher

published in

• Journal of the American Chemical Society  Journal

keywords

• Bacillus Subtilis
• Bacterial Proteins
• Biocatalysis
• Carbon-nitrogen Lyases
• Molecular Structure
• Thiamine
• Thiazoles

PubMed Central ID

• 19216519

Digital Object Identifier (DOI)

• 10.1021/ja806752h

start page

• 3225

end page

• 3229

volume

• 131

issue

• 9

URL

• http://dx.doi.org/10.1021/ja806752h