A Remarkable Oxidative Cascade That Replaces the Riboflavin C8 Methyl with an Amino Group during Roseoflavin Biosynthesis. Academic Article

abstract

• Roseoflavin is a naturally occurring riboflavin analogue with antibiotic properties. It is biosynthesized from riboflavin in a reaction involving replacement of the C8 methyl with a dimethylamino group. Herein we report the identification of a flavin-dependent enzyme that converts flavin mononucleotide (FMN) and glutamate to 8-amino-FMN via the intermediacy of 8-formyl-FMN. A mechanistic proposal for this remarkable transformation is proposed.

authors

• Begley, Tadhg

published proceedings

• J Am Chem Soc

altmetric score

• 0.25

author list (cited authors)

• Jhulki, I., Chanani, P. K., Abdelwahed, S. H., & Begley, T. P.

citation count

• 14

complete list of authors

• Jhulki, Isita||Chanani, Prem K||Abdelwahed, Sameh H||Begley, Tadhg P

publication date

• July 2016

publisher

• American Chemical Society (ACS)  Publisher

published in

• Journal of the American Chemical Society  Journal

keywords

• Flavin Mononucleotide
• Oxidation-Reduction
• Riboflavin
• Streptomyces

PubMed Central ID

• 27331868

Digital Object Identifier (DOI)

• 10.1021/jacs.6b02469

start page

• 8324

end page

• 8327

volume

• 138

issue

• 27

URL

• http://dx.doi.org/10.1021/jacs.6b02469