A Remarkable Oxidative Cascade That Replaces the Riboflavin C8 Methyl with an Amino Group during Roseoflavin Biosynthesis.
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Roseoflavin is a naturally occurring riboflavin analogue with antibiotic properties. It is biosynthesized from riboflavin in a reaction involving replacement of the C8 methyl with a dimethylamino group. Herein we report the identification of a flavin-dependent enzyme that converts flavin mononucleotide (FMN) and glutamate to 8-amino-FMN via the intermediacy of 8-formyl-FMN. A mechanistic proposal for this remarkable transformation is proposed.
author list (cited authors)
Jhulki, I., Chanani, P. K., Abdelwahed, S. H., & Begley, T. P.
complete list of authors
Jhulki, Isita||Chanani, Prem K||Abdelwahed, Sameh H||Begley, Tadhg P