Ganglioradiculitis (sensory neuronopathy) in a dog: clinical, morphologic, and immunohistochemical findings. Academic Article

abstract

• A 9-year-old Labrador Retriever was diagnosed with ganglioradiculitis (sensory neuronopathy). This idiopathic disease of mature dogs is characterized by a profound loss of sensory nerve function due to mononuclear inflammatory infiltration of peripheral ganglia and spinal nerve roots, with destruction of sensory neurons. Immunohistochemistry demonstrates that the infiltrating cells are primarily T lymphocytes and that immunoglobulins are not present on the cell membranes of affected neurons. The pathogenesis of ganglioradiculitis remains unclear, but the evidence points to a cell-mediated immune mechanism.

authors

• Porter, Brian

published proceedings

• Vet Pathol

author list (cited authors)

• Porter, B., Schatzberg, S., McDonough, S., Mertens, D., & de Lahunta, A.

citation count

• 11

complete list of authors

• Porter, B||Schatzberg, S||McDonough, S||Mertens, D||de Lahunta, A

publication date

• September 2002

publisher

• SAGE Publications  Publisher

published in

• Veterinary Pathology  Journal

keywords

• Adrenal Cortex Hormones
• Animals
• Dog Diseases
• Dogs
• Fatal Outcome
• Female
• Immunohistochemistry
• Polyradiculoneuropathy
• Salivation

PubMed Central ID

• 12243475

Digital Object Identifier (DOI)

• 10.1354/vp.39-5-598

start page

• 598

end page

• 602

volume

• 39

issue

• 5

URL

• http://dx.doi.org/10.1354/vp.39-5-598