Polyarteritis nodosa in a cynomolgus macaque (Macaca fascicularis). Academic Article

abstract

• Polyarteritis nodosa (PAN) is an idiopathic necrotizing vasculitis affecting small- to medium-sized arteries. The disease is well recognized in humans, and PAN-like syndromes have been described in a number of other species. This report describes a case of PAN in a 6-year-old male cynomolgus macaque. The animal had necrotizing arteritis affecting vessels in the kidney, small intestine, colon, heart, spleen, mesentery, urinary bladder, and pancreas. The lesions were segmental in distribution and of varying severity and stage of development. A transmural mixed inflammatory cell infiltrate was present, often accompanied by fibrinoid necrosis of the tunica media and loss of the internal elastic lamina. Immunohistochemical staining showed that many of the infiltrating cells were T lymphocytes and histiocytes, suggesting a cell-mediated component to the pathogenesis.

authors

• Porter, Brian

published proceedings

• Vet Pathol

author list (cited authors)

• Porter, B. F., Frost, P., & Hubbard, G. B.

citation count

• 34

complete list of authors

• Porter, BF||Frost, P||Hubbard, GB

publication date

• September 2003

publisher

• SAGE Publications  Publisher

published in

• Veterinary Pathology  Journal

keywords

• Animals
• Fatal Outcome
• Immunohistochemistry
• Intestine, Small
• Kidney
• Macaca Fascicularis
• Male
• Mesenteric Arteries
• Monkey Diseases
• Polyarteritis Nodosa

PubMed Central ID

• 12949416

Digital Object Identifier (DOI)

• 10.1354/vp.40-5-570

start page

• 570

end page

• 573

volume

• 40

issue

• 5

URL

• http://dx.doi.org/10.1354/vp.40-5-570