Rational emotive behavior therapy (REBT) can be an elegant treatment modality for explicitly religious clients. This is true in spite of the traditional antireligious stance of Albert Ellis. In this article, the authors summarize the evolution of Ellis's views on religion and mental health, consider potential ethical dilemmas caused by utilizing REBT with religious clients, and recommend strategies for reducing violation of ethical and specialty guidelines in work with religious clients. The authors conclude by proposing a general model for religiously sensitive psychotherapy, which may serve to undergird theorizing and research on the application of REBT and other treatment approaches to religious clients.