The organometallic active site of [Fe]hydrogenase: models and entatic states. Academic Article uri icon


  • The simple organometallic, (mu-S(2))Fe(2)(CO)(6), serves as a precursor to synthetic analogues of the chemically rudimentary iron-only hydrogenase enzyme active site. The fundamental properties of the (mu-SCH(2)CH(2)CH(2)S)[Fe(CO)(3)](2) compound, including structural mobility and regioselectivity in cyanidecarbon monoxide substitution reactions, relate to the enzyme active site in the form of transition-state structures along reaction paths rather than ground-state structures. Even in the absence of protein-based active-site organization, the ground-state structural model complexes are shown to serve as hydrogenase enzyme reaction models, H(2) uptake and H(2) production, with the input of photo- or electrochemical energy, respectively.

published proceedings

  • Proc Natl Acad Sci U S A

altmetric score

  • 6

author list (cited authors)

  • Darensbourg, M. Y., Lyon, E. J., Zhao, X., & Georgakaki, I. P.

citation count

  • 260

complete list of authors

  • Darensbourg, Marcetta Y||Lyon, Erica J||Zhao, Xuan||Georgakaki, Irene P

publication date

  • April 2003