The presence of pore water in mixtures can cause premature failure of hot-mix asphalt pavements. The processes typically associated with moisture damage are complex and occur over a long period of time in the field. Short of being able to simulate each of the possible mechanisms of moisture damage directly, the ideal laboratory-based conditioning system should accelerate the penetration of moisture through the asphalt film and at the same time minimize complicating effects. This paper presents the results of an experiment conducted to determine whether it was possible to use cyclic pore pressures to induce enough damage to distinguish between mixtures known to be highly resistant from mixtures known to be susceptible to moisture damage. Experimental constraints included requirements that conditioning be accomplished within a reasonable length of time and that typical laboratory equipment be used. Evaluation of the resulting effects of moisture damage included the use of the Superpave indirect tension test and the energy ratio parameter. Findings show that cyclic pore pressures can be used to accelerate moisture damage enough to distinguish between mixtures known to be strippers and those known to be highly resistant to moisture damage. The use of cyclic pore pressures to accelerate moisture damage in mixtures may minimize the introduction of other confounding damage effects on the mixtures.