Usefulness of Released Cardiac Myosin Binding Protein-C as a Predictor of Cardiovascular Events. uri icon

abstract

  • Cardiac myosin binding protein-C (cMyBP-C) is a heart muscle-specific thick filament protein. Elevated level of serum cMyBP-C is an indicator of early myocardial infarction (MI), but its value as a predictor of future cardiovascular disease is unknown. Based on the presence of significant amount of cMyBP-C in the serum of previous study subjects independent of MI, we hypothesized that circulating cMyBP-C is a sensitive indicator of ongoing cardiovascular stress and disease. To test this hypothesis, 75 men and 83 women of similar ages were recruited for a prospective study. They underwent exercise stress echocardiography to provide pre- and poststress blood samples for subsequent determination of serum cMyBP-C levels. The subjects were followed for 1 to 1.5 years. Exercise stress increased serum cMyBP-C in all subjects. Twenty-seven primary events (such as death, MI, revascularization, invasive cardiovascular procedure, or cardiovascular-related hospitalization) and 7 critical events (CE; such as death, MI, stroke, or pulmonary embolism) occurred. After adjusting for sex and cardiovascular risk factors with multivariate Cox regression, a 96% sensitive prestress cMyBP-C threshold carried a hazard ratio of 8.1 with p=0.041 for primary events. Most subjects (6 of 7) who had CE showed normal ejection fraction on echocardiography. Prestress cMyBP-C demonstrated area under receiver operating curve of 0.91 and multivariate Cox regression hazard ratio of 13.8 (p=0.000472) for CE. Thus, basal cMyBP-C levels reflected susceptibility for a variety of cardiovascular diseases. Together with its high sensitivity, cMyBP-C holds potential as a screening biomarker for the existence of severe cardiovascular diseases.

published proceedings

  • Am J Cardiol

altmetric score

  • 1

author list (cited authors)

  • Tong, C. W., Dusio, G. F., Govindan, S., Johnson, D. W., Kidwell, D. T., De La Rosa, L. M., ... Sadayappan, S.

citation count

  • 4

complete list of authors

  • Tong, Carl W||Dusio, Giuseppina F||Govindan, Suresh||Johnson, Dustin W||Kidwell, David T||De La Rosa, Lisa M||Rosas, Paola C||Liu, Yang||Ebert, Elizabeth||Newell-Rogers, M Karen||Michel, Jeffrey B||Trzeciakowski, Jerome P||Sadayappan, Sakthivel

publication date

  • January 2017