Genetic variation at a locus (TAM-1) for submaxillary gland protease in the mouse and its location on chromosome No. 7. Academic Article

abstract

• Electrophoretic and activity variants for a testosterone-induced esteroprotease have been discovered in submaxillary glands from inbred strains of mice. The enzyme is tentatively designated tamase [TAM-1] and the variant genetic locus is Tam-1. The alleles Tam-1a and Tam-1b determine electrophoretically distinct zones of tamase activity, while Tam-lc produces no detectable enzyme activity. Data from recombinant inbred strains and B6AF1 X B6 and B6D2F1 X B6 backcrosses established linkage of Tam-1 to glucose phosphate isomerase (Gpi-1), pink-eyed dilution [p] and beta-hemoglobin (Hbb) on chromosome 7. The gene order is Gpi-1--Tam-1--p--HBB. Analysis of congenic resistant strains indicates that Tam-1 is closely linked to the minor histocompatibility locus, H-4. TAM-1 was not cross-reactive with antisera to mouse nerve growth factor, submaxillary renin, or tamases A and D.

authors

• Skow, Loren

published proceedings

• Genetics

author list (cited authors)

• Skow, L. C.

citation count

• 27

complete list of authors

• Skow, LC

publication date

• December 1978

publisher

• Oxford University Press (OUP)  Publisher

published in

• Genetics  Journal

keywords

• Animals
• Chromosome Mapping
• Crosses, Genetic
• Electrophoresis, Cellulose Acetate
• Female
• Genes
• Genetic Variation
• History, 18th Century
• Male
• Mice
• Mice, Inbred Strains
• Peptide Hydrolases
• Submandibular Gland

PubMed Central ID

• 744473

Digital Object Identifier (DOI)

• 10.1093/genetics/90.4.713

start page

• 713

end page

• 724

volume

• 90

issue

• 4

URL

• http://dx.doi.org/10.1093/genetics/90.4.713