Electrophoretic variation in low molecular weight lens crystallins from inbred strains of rats. Academic Article

abstract

• Analysis of rat lens soluble proteins by analytical isoelectric focusing detected two inherited electrophoretic differences in low molecular weight (LM) crystallins from inbred strains of rats (Rattus norvegicus). The polymorphic lens crystallins were shown to be similar to a genetically variant LM crystallin, LEN-1, previously described in mice (Mus musculus) and encoded on chromosome 1, at a locus linked to Pep-3 (dipeptidase). Linkage analysis demonstrated that the rat crystallin locus was loosely linked to Pep-3 at a recombination distance of 38 +/- 4.5 U. These data suggest the conservation of a large chromosomal region during the evolution of Rodentia and support the hypothesis that the gamma-crystallins are evolving more rapidly than alpha- or beta-crystallins.

authors

• Skow, Loren

published proceedings

• Biochem Genet

author list (cited authors)

• Donner, M. E., Skow, L. C., Kunz, H. W., & Gill, T. J.

citation count

• 4

complete list of authors

• Donner, ME||Skow, LC||Kunz, HW||Gill, TJ

publication date

• October 1985

publisher

• Springer Nature  Publisher

keywords

• Animals
• Crosses, Genetic
• Crystallins
• Electrophoresis, Polyacrylamide Gel
• Female
• Genetic Linkage
• Genetic Variation
• Immunodiffusion
• Isoelectric Focusing
• Male
• Molecular Weight
• Phenotype
• Rats
• Rats, Inbred Strains
• Species Specificity

PubMed Central ID

• 3936479

Digital Object Identifier (DOI)

• 10.1007/BF02399409

start page

• 787

end page

• 800

volume

• 23

issue

• 9-10

URL

• http://dx.doi.org/10.1007/bf02399409