Dominant visible and electrophoretically expressed mutations induced in male mice exposed to ethylene oxide by inhalation. Academic Article uri icon

abstract

  • The offspring of DBA/2J male mice exposed to ethylene oxide (EtO) by inhalation had an increased incidence of both dominant visible and electrophoretically detected mutations over that found in control populations. The progeny at risk were obtained from matings during the exposure period and were the products of germ cells that were exposed throughout the entire spermatogenic process. The results reported here suggest that male germ cells repeatedly exposed to EtO during spermatogenesis are susceptible to EtO-induced transmissible damage.

published proceedings

  • Environ Mutagen

altmetric score

  • 3

author list (cited authors)

  • Lewis, S. E., Barnett, L. B., Felton, C., Johnson, F. M., Skow, L. C., Cacheiro, N., & Shelby, M. D.

citation count

  • 37

complete list of authors

  • Lewis, SE||Barnett, LB||Felton, C||Johnson, FM||Skow, LC||Cacheiro, N||Shelby, MD

publication date

  • January 1986

publisher