Experimental induction of rheumatoid factor and joint lesions in rabbits after intravenous injections of killed bacteria. Academic Article uri icon


  • Rabbits receiving repeated intravenous injections of killed bacteria (Escherichia coli or Bacillus subtilis) developed IgM rheumatoid factor which reacted with autologous heat-aggregated IgG. In addition, 5/7 'Old English' and 7/8 'Sandy Lop' rabbits receiving killed E. coli developed rheumatoid-like synovial lesions. 'Old English' rabbits developed lesions of a more severe nature. Three of eight 'Sandy Lop' rabbits injected with killed B. subtilis had high levels of rheumatoid factor but only mild joint lesions.

author list (cited authors)

  • Hanglow, A. C., Welsh, C. J., Conn, P., Pitts, J. M., Rampling, A., & Coombs, R. R.

citation count

  • 16

publication date

  • January 1986


  • BMJ  Publisher