Experimental induction of rheumatoid factor and joint lesions in rabbits after intravenous injections of killed bacteria. Academic Article

abstract

• Rabbits receiving repeated intravenous injections of killed bacteria (Escherichia coli or Bacillus subtilis) developed IgM rheumatoid factor which reacted with autologous heat-aggregated IgG. In addition, 5/7 'Old English' and 7/8 'Sandy Lop' rabbits receiving killed E. coli developed rheumatoid-like synovial lesions. 'Old English' rabbits developed lesions of a more severe nature. Three of eight 'Sandy Lop' rabbits injected with killed B. subtilis had high levels of rheumatoid factor but only mild joint lesions.

authors

• Welsh, Christabel Jane

published proceedings

• Ann Rheum Dis

author list (cited authors)

• Hanglow, A. C., Welsh, C. J., Conn, P., Pitts, J. M., Rampling, A., & Coombs, R. R.

citation count

• 16

complete list of authors

• Hanglow, AC||Welsh, CJ||Conn, P||Pitts, JM||Rampling, A||Coombs, RR

publication date

• January 1986

publisher

• BMJ  Publisher

published in

• ANNALS OF THE RHEUMATIC DISEASES  Journal

keywords

• Animals
• Antibodies, Bacterial
• Bacillus Subtilis
• Escherichia Coli
• Immunoglobulin G
• Immunoglobulin M
• Joint Diseases
• Rabbits
• Rheumatoid Factor
• Synovial Fluid

PubMed Central ID

• 3082299

Digital Object Identifier (DOI)

• 10.1136/ard.45.1.50

start page

• 50

end page

• 59

volume

• 45

issue

• 1

URL

• http://dx.doi.org/10.1136/ard.45.1.50