Effects of purified components of jellyfish toxin (Stomolophus meleagris) on adenosine triphosphatase activities.
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abstract
Toxin from the jellyfish Stomolophus meleagris was found to stimulate both Na+-K+ and mitochondrial Mg2+ ATPase activities at low toxin concentrations and to inhibit these ATPase activities at higher (> 02 mg/ml) concentrations. Using discontinuous membrane partition chromatography the toxin was fractionated into six fractions. Of these six fractions, one strongly activated when five inhibited mitochondrial Mg2+ ATPase. One fraction strongly activated, a second mildly activated, while the other four inhibited Na+-K+ ATPase about 50 per cent. Only two fractions affected oligomycin-insensitive ATPase, and both of these exhibited a mild stimulation. It is concluded that the ability of this toxin to alter membrane permeability to Na+ is due, at least in part, to components in the toxin which act directly on ATPase. 1976.