Effects of purified components of jellyfish toxin (Stomolophus meleagris) on adenosine triphosphatase activities. Academic Article

abstract

• Toxin from the jellyfish Stomolophus meleagris was found to stimulate both Na+-K+ and mitochondrial Mg2+ ATPase activities at low toxin concentrations and to inhibit these ATPase activities at higher (> 02 mg/ml) concentrations. Using discontinuous membrane partition chromatography the toxin was fractionated into six fractions. Of these six fractions, one strongly activated when five inhibited mitochondrial Mg2+ ATPase. One fraction strongly activated, a second mildly activated, while the other four inhibited Na+-K+ ATPase about 50 per cent. Only two fractions affected oligomycin-insensitive ATPase, and both of these exhibited a mild stimulation. It is concluded that the ability of this toxin to alter membrane permeability to Na+ is due, at least in part, to components in the toxin which act directly on ATPase. 1976.

authors

• Phillips, Timothy

published proceedings

• Biochem Pharmacol

author list (cited authors)

• Toom, P. M., & Phillips, T. D.

citation count

• 4

complete list of authors

• Toom, PM||Phillips, TD

publication date

• March 1976

publisher

• Elsevier  Publisher

published in

• Biochemical Pharmacology  Journal

keywords

• Adenosine Triphosphatases
• Animals
• Biological Transport
• Brain
• Cnidaria
• In Vitro Techniques
• Magnesium
• Marine Toxins
• Mitochondria
• Molecular Weight
• Potassium
• Rats
• Sodium

PubMed Central ID

• 8052

Digital Object Identifier (DOI)

• 10.1016/0006-2952(76)90387-7

start page

• 551

end page

• 555

volume

• 25

issue

• 5

URL

• http://dx.doi.org/10.1016/0006-2952(76)90387-7