Inhibition of electrogenic sodium transport across toad urinary bladder by the mycotoxin patulin. Academic Article

abstract

• The effects of the mycotoxin patulin (4-hydroxy-4H-furo[3,2c]pyran-2(6H)-one) on short circuited intact toad bladder and on Na+-K+, activated ATPase were examined in an attempt to elucidate the relationship between toxin, the Na+-K+ ATPase enzyme system and associated active sodium transport. Patulin inhibited transbladder short circuit current and Na+-K+ ATPase from isolated bladder preprations. The effect was exponentially dependent on time. A significantly slower rate of inhibition was achieved within 15-30 min. The results are compatible with the assumption that Na+-K+ ATPase is associated with the pump mechanism since patulin inhibited enzyme activity and concomitantly reduced the rate of electrogenic Na+ transport. A significant correlation suggested a cause-effect relationship.

authors

• Phillips, Timothy

published proceedings

• Toxicology

author list (cited authors)

• Phillips, T. D., & Hayes, A. W.

citation count

• 11

complete list of authors

• Phillips, TD||Hayes, AW

publication date

• May 1979

publisher

• Elsevier  Publisher

published in

• Toxicology  Journal

keywords

• Animals
• Biological Transport, Active
• Bufo Marinus
• Cell Membrane Permeability
• Patulin
• Pyrans
• Sodium
• Sodium-Potassium-Exchanging ATPase
• Time Factors
• Urinary Bladder

PubMed Central ID

• 229586

Digital Object Identifier (DOI)

• 10.1016/s0300-483x(79)80005-0

start page

• 17

end page

• 24

volume

• 13

issue

• 1

URL

• http://dx.doi.org/10.1016/s0300-483x(79)80005-0