Effects of mycotoxins on mixed-function oxidase and adenosine triphosphatase systems in neonatal rats. I. Aflatoxin B1/rubratoxin B Academic Article uri icon

abstract

  • The effects of aflatoxin B1 and/or rubratoxin B on hepatic monooxygenase and hepatic, brain and renal ATPase activities were examined in neonatal rats exposed to a single treatment of one or both toxins. Animals received orally 0·4 mg aflatoxin B1/kg, 2 mg rubratoxin B/kg or the same doses of aflatoxin B1 and rubratoxin B in combination, within 24 hr of birth, and were killed 12 days later. Given alone, rubratoxin B caused a statistically significant decrease in cytochrome P-450 content. Hepatic and renal oligomycin-sensitive ATPase activity was depressed by the aflatoxin B1 and rubratoxin B combination but this effect appeared to be the result of the aflatoxin treatment. The only interaction observed after exposure of pups to the mycotoxin combination was a tendency towards a decrease in NADPH-dependent dehydrogenase. © 1980.

author list (cited authors)

  • Phillips, T. D., Siraj, M. Y., & Hayes, A. W.

citation count

  • 2

complete list of authors

  • Phillips, TD||Siraj, MY||Hayes, AW

publication date

  • January 1980