Effects of mycotoxins on mixed-function oxidase and adenosine triphosphatase systems in neonatal rats. I. aflatoxin B1/rubratoxin B.
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abstract
The effects of aflatoxin B1 and/or rubratoxin B on hepatic monooxygenase and hepatic, brain and renal ATPase activities were examined in neonatal rats exposed to a single treatment of one or both toxins. Animals received orally 04 mg aflatoxin B1/kg, 2 mg rubratoxin B/kg or the same doses of aflatoxin B1 and rubratoxin B in combination, within 24 hr of birth, and were killed 12 days later. Given alone, rubratoxin B caused a statistically significant decrease in cytochrome P-450 content. Hepatic and renal oligomycin-sensitive ATPase activity was depressed by the aflatoxin B1 and rubratoxin B combination but this effect appeared to be the result of the aflatoxin treatment. The only interaction observed after exposure of pups to the mycotoxin combination was a tendency towards a decrease in NADPH-dependent dehydrogenase. 1980.