Conversion of rubratoxin B to the carboxylic acid derivative and its effect on adenosine triphosphatase activity and toxicity to mice. Academic Article uri icon

abstract

  • The rate of conversion of rubratoxin B to its carboxylic acid derivative upon exposure to aqueous solvents was exponentially related to the relative abundance of water molecules. The same relationship existed for the rate of decrease in inhibition of Na+-K+ adenosine triphosphatase (ATPase) activity by rubratoxin B, when the toxin was incubated in the reaction mixture prior to addition of the enzyme. Inhibition of this enzyme activity by rubratoxin B was dose-dependent, with an IC50 of 5.8 x 10-6M, while the carboxylic acid derivative was much less effective, the IC50 being 19.3 x 10-6M. In mice, the ip LD50 of the carboxylic acid derivative dissolved in propylene glycol was more than twice that of the parent compound 24 hr after dosing, but beyond 24 hr there was little difference between the two values.

published proceedings

  • Food Cosmet Toxicol

altmetric score

  • 3

author list (cited authors)

  • Unger, P. D., Phillips, T. D., & Hayes, A. W.

citation count

  • 7

complete list of authors

  • Unger, PD||Phillips, TD||Hayes, AW

publication date

  • October 1978