Effects of the aflatoxins on ATPase activities in mouse and rat liver. Academic Article

abstract

• The effects of the aflatoxins on ATPase activities in mouse and rat tissues were investigated in vitro. The hepatic oligomycin-sensitive (O.S.) Mg++ ATPase was inhibited significantly. The order of inhibition was G1 greater than B1 greater than G2 greater than B2. Mouse O.S. Mg++ ATPase was more sensitive than the corresponding rat enzyme. The oligomycin-insensitive (O.I.) Mg++ ATPase activities in rat and mouse liver were not altered. Although aflatoxins G1 and B1 were more potent inhibitors of hepatic O.S. Mg++ ATPase, no concentration-response was observed, whereas aflatoxins G2 and B2 inhibited enzyme activity in a concentration-dependent manner. Spectral analysis of aflatoxin G1 solutions suggested that solubility was not related to the observed effects. In addition, the effects of aflatoxin B1 and G1 on mouse brain microsomal Na+-K+ ATPase were examined. Although aflatoxin B1 was more potent that G1, both mycotoxins significantly inhibited enzyme activity in a concentration-dependent fashion.

authors

• Phillips, Timothy

published proceedings

• J Environ Sci Health B

author list (cited authors)

• Desaiah, D., Phillips, T. D., Hayes, A. W., & Ho, I. K.

citation count

• 11

complete list of authors

• Desaiah, D||Phillips, TD||Hayes, AW||Ho, IK

publication date

• January 1979

publisher

• Taylor & Francis  Publisher

published in

• Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes  Journal

keywords

• Adenosine Triphosphatases
• Aflatoxins
• Animals
• Brain
• Liver
• Magnesium
• Male
• Mice
• Mice, Inbred ICR
• Microsomes
• Mitochondria, Liver
• Oligomycins
• Rats
• Sodium-Potassium-Exchanging ATPase
• Species Specificity

PubMed Central ID

• 220299

Digital Object Identifier (DOI)

• 10.1080/03601237909372127

start page

• 265

end page

• 278

volume

• 14

issue

• 3

URL

• http://dx.doi.org/10.1080/03601237909372127