Effects of the mycotoxins citrinin and ochratoxin a on hepatic mixed-function oxidase and adenosinetriphosphatase in neonatal rats. Academic Article

abstract

• The effects of citrinin, ochratoxin A, or a combination of the two mycotoxins on the hepatic monooxygenase system and on hepatic and renal adenosinetriphosphatase (ATPase) activities were examined in neonatal rats exposed to a single treatment of one or both toxins. Animals received (po) 25 mg/kg citrinin, 1 mg/kg ochratoxin A, or 25 mg/kg citrinin plus 1 mg/kg ochratoxin A within 24 h of birth. Pups were killed 12 d later. Citrinin or ochratoxin A alone did not affect hepatic ATPase. Renal oligomycin-sensitive Mg2+-ATPase was inhibited to the same degree by ochratoxin A and the combination treatment. A synergistic effect of the two mycotoxins was observed on renal Na+-K+-ATPase. Significant effects, due to the mycotoxin interaction, were also observed on cytochrome P-450 content, NADPH-dependent dehydrogenase, and NADPH-cytochrome c reductase.

authors

• Phillips, Timothy

published proceedings

• J Toxicol Environ Health

altmetric score

• 3

author list (cited authors)

• Siraj, M. Y., Phillips, T. D., & Hayes, A. W.

citation count

• 22

complete list of authors

• Siraj, MY||Phillips, TD||Hayes, AW

publication date

• July 1981

publisher

• Taylor & Francis  Publisher

published in

• Journal of Toxicology and Environmental Health  Journal

keywords

• Adenosine Triphosphatases
• Animals
• Animals, Newborn
• Benzopyrans
• Citrinin
• Drug Combinations
• Kidney
• Liver
• Mixed Function Oxygenases
• Ochratoxins
• Oxidoreductases
• Rats
• Rats, Inbred Strains

PubMed Central ID

• 6460115

Digital Object Identifier (DOI)

• 10.1080/15287398109530057

start page

• 131

end page

• 140

volume

• 8

issue

• 1-2

URL

• http://dx.doi.org/10.1080/15287398109530057