High prevalence of serum antibodies to equine infectious anemia virus reverse transcriptase. Academic Article

abstract

• The immunogenicity of the equine infectious anemia virus (EIAV) reverse transcriptase (RT) was examined by immunoblot assay with recombinant EIAV RT. All of the 19 sera from EIAV-infected horses tested contained antibodies that recognized EIAV RT and directly inhibited the polymerase activity of the enzyme. An examination of sera obtained sequentially from two experimentally infected animals revealed that anti-RT antibodies arise early in infection and increase in level. The appearance of the antibodies correlated with progression toward the asymptomatic period of infection.

authors

• Payne, Susan

published proceedings

• AIDS Res Hum Retroviruses

author list (cited authors)

• DeVico, A. L., Issel, C. J., Le Grice, S. F., Payne, S. L., Montelaro, R. C., & Sarngadharan, M. G.

citation count

• 1

complete list of authors

• DeVico, AL||Issel, CJ||Le Grice, SF||Payne, SL||Montelaro, RC||Sarngadharan, MG

publication date

• January 1993

publisher

• Mary Ann Liebert  Publisher

published in

• AIDS RESEARCH AND HUMAN RETROVIRUSES  Journal

keywords

• Animals
• Antibodies, Viral
• Cross Reactions
• Equine Infectious Anemia
• Horses
• Immunoblotting
• Infectious Anemia Virus, Equine
• RNA-Directed DNA Polymerase
• Recombinant Proteins

PubMed Central ID

• 7678974

Digital Object Identifier (DOI)

• 10.1089/aid.1993.9.7

start page

• 7

end page

• 11

volume

• 9

issue

• 1

URL

• http://dx.doi.org/10.1089/aid.1993.9.7

user-defined tag

• 3 Good Health and Well-Being