Towards optical brain imaging: getting light through a bone Academic Article uri icon


  • 2017 Informa UK Limited, trading as Taylor & Francis Group. Optical imaging and detection in biological samples is severely limited by scattering effects. In particular, optical techniques for measuring conditions beneath the skull and within the bone marrow hold significant promise when it comes to speed, sensitivity and specificity. However, the strong optical scattering due to bone hinders the realization of these methods. In this article, we propose a technique to enhance the transmittance of light through bone. This is achieved by injecting light below the top surface of the bone and utilizing multiple scattering to increase transmittance. This technique suggests that enhancements of 26 times may be realized by injection of light 1mm below the surface of the bone. By enhancing the transmittance of light through bone, we will greatly improve our ability to utilize optical methods to better understand and diagnose conditions within biological media.

published proceedings


author list (cited authors)

  • Thompson, J. V., Hokr, B. H., Nodurft, D. T., & Yakovlev, V. V.

citation count

  • 0

complete list of authors

  • Thompson, JV||Hokr, BH||Nodurft, DT||Yakovlev, VV

publication date

  • July 2018