Oscillatory equi-biaxial strain activates JNK in a frequency-dependent manner in bovine aortic endothelial cells Conference Paper uri icon


  • Cultured bovine aortic endothelial cells were subjected to either laminar fluid shear stress or equi-biaxial stretch. A step equi-biaxial stretch with an area increase of 25% resulted in a negligible increase in endogenous JNK1 kinase activity compared to cells in static condition. In contrast, a sinusoidal stretch with an area change from 0 to 25% resulted in a sustained increase in JNK1 activity up to 12 hr of stretch. Furthermore, the magnitude of activity varied directly with the frequency of oscillatory stretch in the range of 0.01 to 1 Hz. A step change in fluid shear stress from 0 to 16 dyn/cm2 resulted in transient JNK1 activation which peaked at 60 min and returned to baseline levels after 12 hr of shear stress. A similar time course of JNK1 activation was observed upon application of shear stress with the amplitude oscillating between 0 and 16 dyn/cm2 at a frequency of 1 Hz.

name of conference

  • Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. No.99CH37015)

published proceedings

  • Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

author list (cited authors)

  • Kaunas, R., Shyy, J. Y., & Chien, S.

citation count

  • 0

complete list of authors

  • Kaunas, R||Shyy, JY||Chien, S

publication date

  • January 1999