Study of transport phenomena of FITC labeled dextran through nano self assembled microshells Academic Article uri icon


  • The transport characteristics of hollow shells formed via self assembly of polyelectrolytes was the focus of this study. The shells were formed by layering on 5 m diameter sacrificial cores that were subsequently dissolved in an acidic media. The effect of two polyanions was compared: polyvinyl sulfonate (PVS) and polystyrene sulfonate (PSS) along with two polycations: polyallylamine hydrochloride (PAH), and polydimethyldiallyl ammonium (PDDA). The number of polyelectrolyte bilayers was varied from 2, 4, and 6. The diffusion of fluorescein-isothiocyanate (FITC) labeled dextran was monitored over a period of days after loading times of 12, 36, or 60 h. Loading was also characterized using confocal laser scanning microscopy (CLSM). Two molecular weights of FITC labeled dextran, 4000 and 77,000, were utilized in this study. The choice in polycation results in the largest changes in wall permeability for the neutral pH tested. PDDA architectures produce a higher permeability than PAH structures. Loading of 77,000 MW FITC-dextran was observed in both the PVS/PDDA and PSS/PDDA structures. 2004 Elsevier B.V. All rights reserved.

published proceedings


author list (cited authors)

  • Gupta, N., Patel, A. A., Nassar, R., Lvov, Y. M., McShane, M. J., & Palmer, J. D.

citation count

  • 12

complete list of authors

  • Gupta, N||Patel, AA||Nassar, R||Lvov, YM||McShane, MJ||Palmer, JD

publication date

  • January 2004