Intrinsic optical signal imaging of a ratiometric fluorescence oxygen nanosensor Conference Paper uri icon

abstract

  • Several imaging techniques and methods have been developed to map the metabolic or electrical changes during brain functions in high spatial and temporal resolutions. Wide-field intrinsic optical signal (IOS) imaging is an excellent method for its spatial resolution of 50-100m and a wide imaging field of several mm 2 that cannot be achieved by any microscope. A nano-encapsulated fluorescence dye sensor that is specifically sensitive to oxygen level was fabricated. The fluorescence images of the nanosensor were collected by a wide-field IOS imaging system under two different oxygen concentrations and analyzed by MATLAB software for the nanosensor's oxygen quenching property. 2005 IEEE.

name of conference

  • 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology

published proceedings

  • 2005 3RD IEEE/EMBS SPECIAL TOPIC CONFERENCE ON MICROTECHNOLOGY IN MEDICINE AND BIOLOGY

author list (cited authors)

  • Zhang, G., Shitole, P. S., Pujari, R. A., Charnani, V. S., McShane, M. J., & Robinson, C. J.

citation count

  • 1

complete list of authors

  • Zhang, G||Shitole, PS||Pujari, RA||Charnani, VS||McShane, MJ||Robinson, CJ

publication date

  • January 2005