Intrinsic optical signal imaging of a ratiometric fluorescence oxygen nanosensor
Conference Paper
Overview
Research
Identity
Additional Document Info
Other
View All
Overview
abstract
Several imaging techniques and methods have been developed to map the metabolic or electrical changes during brain functions in high spatial and temporal resolutions. Wide-field intrinsic optical signal (IOS) imaging is an excellent method for its spatial resolution of 50-100m and a wide imaging field of several mm 2 that cannot be achieved by any microscope. A nano-encapsulated fluorescence dye sensor that is specifically sensitive to oxygen level was fabricated. The fluorescence images of the nanosensor were collected by a wide-field IOS imaging system under two different oxygen concentrations and analyzed by MATLAB software for the nanosensor's oxygen quenching property. 2005 IEEE.
name of conference
2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology