Modeling of selective photon capture for collection of fluorescence emitted from dermally-implanted microparticle sensors.

abstract

• Fluorescence-based sensors have been developed in microsphere formats for many biochemical targets. For these to be deployed in vivo for on-demand monitoring, a matched optical system for delivery of excitation and measurement of emission is needed. To optimize excitation and collection efficiency, statistical ray-tracing may be used to model the distribution of diffusely reflected light resulting from varying input beam profiles. In this work, simulations were performed for models of microsphere fluorescent materials embedded in skin to predict the distribution of excitation and fluorescent photons escaping the skin surface. Simulations prove that the emission photons possess sufficient intensity and spectral information for quantitative analysis. This modeling approach will enable further design of intensity or lifetime instrumentation to maximize signal-to-noise for measurements from implanted sensor particles.

authors

• McShane, Michael

published proceedings

• Annu Int Conf IEEE Eng Med Biol Soc

author list (cited authors)

• Long, R., & McShane, M. J.

citation count

• 4

complete list of authors

• Long, Ruiqi||McShane, Michael J

publication date

• August 2007

publisher

• IEEE  Publisher

published in

• n2375-7477ISSN  Journal

keywords

• Animals
• Computer Simulation
• Humans
• Models, Biological
• Molecular Probe Techniques
• Photons
• Radiation Dosage
• Radiometry
• Reproducibility Of Results
• Scattering, Radiation
• Sensitivity And Specificity
• Skin Physiological Phenomena
• Spectrometry, Fluorescence

Digital Object Identifier (DOI)

• 10.1109/IEMBS.2007.4352953

start page

• 2972

end page

• 2975

volume

• 2007

URL

• http://dx.doi.org/10.1109/iembs.2007.4352953