Effect of high-aspect-ratio microstructures on CeH growth and attachment Conference Paper uri icon

abstract

  • 2000 IEEE. Smooth muscle cells were cultured on a variety of high-aspect-ratio PMMA, PDMS, and SU-S microstructures. Three basic microstructures were used in these experiments: columns, holes, and curved surfaces (microlenses). Typical PMMA features were over 500 m in height, while the SU-S and PDMS structures averaged ISO m in height. The smooth muscle cells showed a clear preference for smooth surfaces as compared to the areas containing microstructures, though smooth muscle cells showed the ability to grow on all structures and to attach on the steep sidewalls associated with the microstructures. Smooth muscle cell alignment was not directly improved by the structures, though evidence indicates that smaller structures may be able to do so. Gap dimensions between columns were also shown to be critical with regard to cell spreading and movement. [1] B. S. Kim and D.J. Mooney, Engineering smooth muscle tissue with a predefined structure. Journal of Biomedical Materials Research, Vol. 41, Pgs. 322-332, 1998.

name of conference

  • 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451)

published proceedings

  • 1ST ANNUAL INTERNATIONAL IEEE-EMBS SPECIAL TOPIC CONFERENCE ON MICROTECHNOLOGIES IN MEDICINE & BIOLOGY, PROCEEDINGS

author list (cited authors)

  • Li, M. Y., Glawe, J. D., Green, H., Mills, D. K., McShane, M. J., & Gale, B. K.

citation count

  • 14

complete list of authors

  • Li, MY||Glawe, JD||Green, H||Mills, DK||McShane, MJ||Gale, BK

publication date

  • January 2000