Hierarchical self-assembly of a coiled-coil peptide into fractal structure.
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Here we report the hierarchical self-assembly of a cross-linkable coiled-coil peptide containing an internal cysteine. Atomic force microscopy (AFM) experiments revealed the fractal structure of the assemblies, and molecular simulations showed that the peptides cross-linked to form clusters of coiled-coils, which further assembled to form globules of tens of nanometers in diameter. Such hierarchical organization was modulated by pH or thiol-reducing agent. Exploitation of the fractal structures through chemical methods may be valuable for the fabrication of materials spanning multiple length scales.
author list (cited authors)
Lomander, A., Hwang, W., & Zhang, S.
complete list of authors
Lomander, Andrea||Hwang, Wonmuk||Zhang, Shuguang