Hierarchical self-assembly of a coiled-coil peptide into fractal structure. Academic Article uri icon


  • Here we report the hierarchical self-assembly of a cross-linkable coiled-coil peptide containing an internal cysteine. Atomic force microscopy (AFM) experiments revealed the fractal structure of the assemblies, and molecular simulations showed that the peptides cross-linked to form clusters of coiled-coils, which further assembled to form globules of tens of nanometers in diameter. Such hierarchical organization was modulated by pH or thiol-reducing agent. Exploitation of the fractal structures through chemical methods may be valuable for the fabrication of materials spanning multiple length scales.

published proceedings

  • Nano Lett

author list (cited authors)

  • Lomander, A., Hwang, W., & Zhang, S.

citation count

  • 87

complete list of authors

  • Lomander, Andrea||Hwang, Wonmuk||Zhang, Shuguang

publication date

  • July 2005