Fluorescence-based implantable biosensors:: Monte Carlo modeling for optical probe design Conference Paper uri icon

abstract

  • Implantable fluorescent sensors may be an attractive solution to the monitoring of many parameters of biomedical interest. A Monte Carlo simulation of photon propagation through human skin and interaction with a subcutaneous fluorescent sensing layer is presented. Results are analyzed with respect to output light intensity as a function of distance from source, input-to-output characteristics; and single-photon versus dual-photon excitation. The results indicate that radial fluorescence erosion profile is broad compared to the diffusely reflected input light. Response intensity has an approximately logarithmic relationship with sensor thickness. Estimated values for tissue autofluorescence quantum yield lead to an approximately inverse relationship between sensor signal-to-noise ratio. One-photon excitation exhibits higher per-photon yield than two-photon excitation.

name of conference

  • Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286)

published proceedings

  • PROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 20, PTS 1-6

author list (cited authors)

  • McShane, M., Rastegar, S., & Cot, G.

citation count

  • 0

complete list of authors

  • McShane, M||Rastegar, S||Coté, G

publication date

  • January 1998