Effects of unilateral ovariectomy on reproductive traits of mice
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The effect of left side unilateral ovariectomy on uterine dimensions, reproductive rate, ovulation of immature ova and embryo development was examined in three experiments. In Experiment I, ovulation rate, implantation rate, litter size and uterine length, wet weight, lyophilized weight and displacement were measured in left side unilaterally ovariectomized and intact control female CF1 mice. No differences were found between treatments for uterine dimensions or ovulation rate. Implantation rate and litter size were smaller (P < 0.05) in unilaterally ovariectomized than in control females. Mortality was increased prior to, rather than after, implantation. In Experiments 2 and 3 incidence of immature ova and abnormal embryos were compared between left side unilaterally ovariectomized and sham operated females. Percentages of immature ova and abnormal embryos were numerically higher for unilaterally ovariectomized females, however, neither difference was significant. Accumulation of the nonsignificant effects of reduced ovulation rate, increased incidence of immature ova and increased incidence of abnormal embryos may play a role in reducing implantation rate and litter size in left side unilaterally ovariectomized mice. 1989.