Effect of an intrauterine foreign body on lysosomal enzyme activity and white blood cell numbers in uterine washings of rats, baboons and humans Academic Article uri icon


  • A comparative study of the effects of an intrauterine foreign body (IUFB) on the concentrations of acid phosphatase and -glucuronidase (lysosomal enzymes), and white blood cells (WBC) in uterine washings of the rat, baboon and human was undertaken, since others had earlier suggested that these factors may be responsible for the embryotoxic effects in rodents. The present studies indicate that in diestrus, estrus, and day 5 post-coitus rats an IUFB induces significant increases in the intrauterine concentrations of lysosomal enzymes and WBC's, and that these changes do not parallel the enzyme concentrations within the uterine tissue itself. By contrast, a foreign body does not significantly influence these parameters in baboons and humans. It is suggested that factors other than those of leucocytic origin may be responsible for the change in intrauterine chemical environment in primates. 1970.

published proceedings

  • Contraception

author list (cited authors)

  • Joshi, S. G., Kraemer, D. C., & Chenault, C. B.

citation count

  • 12

complete list of authors

  • Joshi, Sharad G||Kraemer, Duane C||Chenault, C Brandon

publication date

  • January 1970