Development of mouse embryos in uterine washings of rats and baboons bearing an intrauterine foreign body Academic Article uri icon


  • The development of mouse embryos (8-cell stage) cultured in washings of control and foreign body (FB)-treated rat and baboon uteri was studied in an attempt to detect the presence of embryotoxic factors. The washingts of FB-treated rat uteri were found to be more toxic than those of control uteri. However, mouse embryos developed normally in uterine washings from both control and FB-treated baboons even though the concentration of protein in the baboon fluid was at least ten times greater than that in rat uterine washings. These findings, when considered along with our earlier observations that FB's do not promote increases in intrauterine concentrations of lysosomal enzymes and WBC's in primates, leads to the conclusion that leucocytic factors do not appear to be responsible for any alterations in the biological properties of the uterine fluid of FB-treated primates; further, the data do not support the hypothesis, proposed by others, that the release of intracellular material from FB-damaged cells adversely affects the survival of pre-implantation embryos. 1970.

published proceedings

  • Contraception

author list (cited authors)

  • Joshi, S. G., & Kraemer, D. C.

citation count

  • 13

complete list of authors

  • Joshi, Sharad G||Kraemer, DC

publication date

  • November 1970