Diagnosis of early pregnancy in the baboon.
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Methods for the diagnosis of early pregnancy in the baboon by the detection of chorionic gonadotrophin (CG) in plasma, using radioimmunoassay (RIA), or in the urine by haemagglutination inhibition, as well as by measurement of plasma estrogens and progestins, were compared for their sensitivity, reliability, and rapidity. Detection of CG in the urine by haemagglutination inhibition was unsatisfactory as late as day 25 after conception. On days 8 and 12, measurements of estrogen (E), progesterone (P), or CG in plasma could not be relied upon for confirmation of pregnancy. By day 16, detection of CG in plasma by RIA was successful in 96.6% of cases, but the method was time-consuming. Results of plasma E and P determinations were obtained more quickly, and when evaluated according to a computer-derived formula, were 96.6% successful on that day. 1976 Geron-X, Inc.
author list (cited authors)
Shaikh, A. A., Allen-Rowlands, C., Dozier, T., Kraemer, D. C., & Goldziener, J. W.
complete list of authors
Shaikh, AA||Allen-Rowlands, C||Dozier, T||Kraemer, DC||Goldziener, JW