The paradox of muscle hypertrophy in muscular dystrophy. Academic Article

abstract

• Mutations in the dystrophin gene cause Duchenne and Becker muscular dystrophy in humans and syndromes in mice, dogs, and cats. Affected humans and dogs have progressive disease that leads primarily to muscle atrophy. Mdx mice progress through an initial phase of muscle hypertrophy followed by atrophy. Cats have persistent muscle hypertrophy. Hypertrophy in humans has been attributed to deposition of fat and connective tissue (pseudohypertrophy). Increased muscle mass (true hypertrophy) has been documented in animal models. Muscle hypertrophy can exaggerate postural instability and joint contractures. Deleterious consequences of muscle hypertrophy should be considered when developing treatments for muscular dystrophy.

authors

• Nghiem, Peter

published proceedings

• Phys Med Rehabil Clin N Am

altmetric score

• 3

author list (cited authors)

• Kornegay, J. N., Childers, M. K., Bogan, D. J., Bogan, J. R., Nghiem, P., Wang, J., ... Wagner, K. R.

citation count

• 75

complete list of authors

• Kornegay, Joe N||Childers, Martin K||Bogan, Daniel J||Bogan, Janet R||Nghiem, Peter||Wang, Jiahui||Fan, Zheng||Howard, James F||Schatzberg, Scott J||Dow, Jennifer L||Grange, Robert W||Styner, Martin A||Hoffman, Eric P||Wagner, Kathryn R

publication date

• February 2012

publisher

• Elsevier  Publisher

published in

• Physical Medicine and Rehabilitation Clinics of North America  Journal

keywords

• Animals
• Contracture
• Disease Models, Animal
• Dystrophin
• Humans
• Hypertrophy
• Kyphosis
• Muscle Strength
• Muscle, Skeletal
• Muscular Dystrophies
• Myostatin

PubMed Central ID

• 22239881

Digital Object Identifier (DOI)

• 10.1016/j.pmr.2011.11.014

start page

• 149

end page

• xii

volume

• 23

issue

• 1

URL

• http://dx.doi.org/10.1016/j.pmr.2011.11.014