Toward regulation of gonadal function by a synthetic hybrid molecule composed of gonadotropin and Fc fragment of immunoglobulin G. Academic Article uri icon


  • A conjugate of human chorionic gonadotropin (HCG) and Fc fragment of immunoglobulin G was prepared by covalent cross-linking using the heterobifunctional reagent, N-succinimidyl 3-(2-pyridyldithio) propionate. Mouse Leydig tumor cells expressing receptors for luteinizing hormone were specifically lysed in vitro as a consequence of complement fixation via the Fc component of the hybrid molecule. Furthermore, administration of HCG-Fc to rams caused an acute depression in circulatory testosterone. This novel concept of targeted inhibition of gonadal function could prove to have future applications in control of reproductive processes.

published proceedings

  • Am J Reprod Immunol

altmetric score

  • 3

author list (cited authors)

  • Johnson, G. A., Wilken, C., Van Kirk, E. A., Belden, E. L., & Murdoch, W. J.

citation count

  • 13

complete list of authors

  • Johnson, GA||Wilken, C||Van Kirk, EA||Belden, EL||Murdoch, WJ

publication date

  • May 1990