Autologous olfactory glial cell transplantation is reliable and safe in naturally occurring canine spinal cord injury.

abstract

• Intraspinal transplantation of olfactory glial cells (OGC) has produced well-defined beneficial effects in experimental rodent models of spinal cord injury (SCI) and therefore has considerable promise as a treatment for severe SCI in human patients. In this study, we used clinical canine cases of severe SCI to determine whether derivation and transplantation of OGC from an autologous source was feasible. From the nerve fiber layer of a single olfactory bulb, we were able to generate 5 x 10(6) cells from each patient within 3 weeks. Of this population, 72% were p75(+) OGC, 20% were meningeal cells, and the remainder mainly astrocytes. Intraspinal transplantation was not associated with any observable long- or short-term complications.

authors

• Jeffery, Nicholas

published proceedings

• J Neurotrauma

author list (cited authors)

• Jeffery, N. D., Lakatos, A., & Franklin, R.

citation count

• 73

complete list of authors

• Jeffery, Nick D||Lakatos, Andras||Franklin, Robin JM

publication date

• January 2005

publisher

• Mary Ann Liebert  Publisher

published in

• JOURNAL OF NEUROTRAUMA  Journal

keywords

• Animals
• Biopsy
• Cell Transplantation
• Cells, Cultured
• Defecation
• Dogs
• Gait
• Magnetic Resonance Imaging
• Neuroglia
• Olfactory Bulb
• Pain Threshold
• Recovery Of Function
• Reflex
• Reproducibility Of Results
• Spinal Cord Injuries
• Tissue And Organ Harvesting
• Transplantation, Autologous
• Treatment Outcome
• Urination

PubMed Central ID

• 16305316

Digital Object Identifier (DOI)

• 10.1089/neu.2005.22.1282

start page

• 1282

end page

• 1293

volume

• 22

issue

• 11

URL

• http://dx.doi.org/10.1089/neu.2005.22.1282