Nasal and frontal sinus mucosa of the adult dog contain numerous olfactory sensory neurons and ensheathing glia. Academic Article

abstract

• Olfactory glial cells have been the focus of much recent research interest because of their possible future use as cellular transplants in repair of spinal cord injury. Although olfactory glial cells can be collected from the olfactory bulb for in vitro culture, alternative sites would be preferable for safer surgical access. This study was designed to investigate the distribution of olfactory sensory neurons and olfactory glial cells within the canine peripheral olfactory system. Using immunohistochemistry and electron microscopy on perfused tissue we demonstrate that olfactory sensory neurons are found in both the caudal nasal and the frontal sinus epithelia. Olfactory ensheathing glia were found in the mucosa at both these sites implying that surgical access for harvesting cells for transplantation would be straightforward.

authors

• Jeffery, Nicholas

published proceedings

• Res Vet Sci

author list (cited authors)

• Skinner, A., Pachnicke, S., Lakatos, A., Franklin, R., & Jeffery, N. D.

citation count

• 17

complete list of authors

• Skinner, APC||Pachnicke, S||Lakatos, A||Franklin, RJM||Jeffery, ND

publication date

• January 2005

publisher

• Elsevier  Publisher

published in

• Research in Veterinary Science  Journal

keywords

• Animals
• Dogs
• Frontal Sinus
• Glial Fibrillary Acidic Protein
• Immunohistochemistry
• Nasal Mucosa
• Nerve Tissue Proteins
• Neural Cell Adhesion Molecule L1
• Neuroglia
• Olfactory Bulb
• Olfactory Marker Protein
• Olfactory Receptor Neurons
• Receptor, Nerve Growth Factor
• Sialic Acids

Digital Object Identifier (DOI)

• 10.1016/j.rvsc.2004.05.010

start page

• 9

end page

• 15

volume

• 78

issue

• 1

URL

• http://dx.doi.org/10.1016/j.rvsc.2004.05.010