Perspectives on meningoencephalomyelitis of unknown origin. Academic Article

abstract

• Meningoencephalomyelitis of unknown origin (MUO) is a heterogeneous group of overlapping central nervous system inflammatory diseases of unknown cause. This article highlights the current understanding of MUO and its phenotypic variants encountered in clinical practice. Diagnostic evaluation of presumptive MUO includes lesion distribution on magnetic resonance imaging and ruling out other acquired diseases. Recent evidence provides further knowledge of immune-mediated processes that underlie the pathogenesis of MUO. Current empiric treatment options include corticosteroids and other adjunctive immunomodulating therapies. As the understanding of neuroimmunology and genetic influences on these disorders evolves, a more targeted treatment approach is becoming attainable.

authors

• Jeffery, Nicholas

published proceedings

• Vet Clin North Am Small Anim Pract

altmetric score

• 0.25

author list (cited authors)

• Coates, J. R., & Jeffery, N. D.

citation count

• 64

complete list of authors

• Coates, Joan R||Jeffery, Nicholas D

publication date

• January 2014

publisher

• Elsevier  Publisher

published in

• Veterinary Clinics of North America: Small Animal Practice  Journal

keywords

• Animals
• Central Nervous System
• Dog Diseases
• Dogs
• Glucocorticoids
• Granulomatous Meningoencephalomyelitis
• Immune-mediated
• Immunomodulation
• Immunosuppressive Agents
• Inflammatory
• Meningoencephalitis
• Necrotizing Leukoencephalitis
• Necrotizing Meningoencephalitis

Digital Object Identifier (DOI)

• 10.1016/j.cvsm.2014.07.009

start page

• 1157

end page

• 1185

volume

• 44

issue

• 6

URL

• http://dx.doi.org/10.1016/j.cvsm.2014.07.009