Structural insights into the rhabdovirus transcription/replication complex. Academic Article uri icon

abstract

  • The rhabdoviruses have a non-segmented single stranded negative-sense RNA genome. Their multiplication in a host cell requires three viral proteins in addition to the viral RNA genome. The nucleoprotein (N) tightly encapsidates the viral RNA, and the N-RNA complex serves as the template for both transcription and replication. The viral RNA-dependent RNA polymerase is a two subunit complex that consists of a large subunit, L, and a non-catalytic cofactor, the phosphoprotein, P. P also acts as a chaperone of nascent RNA-free N by forming a N(0)-P complex that prevents N from binding to cellular RNAs and from polymerizing in the absence of RNA. Here, we discuss the recent molecular and structural studies of individual components and multi-molecular complexes that are involved in the transcription/replication complex of these viruses with regard to their implication in viral transcription and replication.

published proceedings

  • Virus Res

author list (cited authors)

  • Ivanov, I., Yabukarski, F., Ruigrok, R., & Jamin, M.

citation count

  • 53

complete list of authors

  • Ivanov, Ivan||Yabukarski, Filip||Ruigrok, Rob WH||Jamin, Marc

publication date

  • January 1, 2011 11:11 AM