Gingival swelling in a 13-year-old girl with multiple recurrences. Academic Article uri icon


  • We present a challenging case of gingival swelling that recurred several times in 3.5 years in a 13-year-old girl. Histologic evaluation of the initial biopsy revealed groups of epithelioid cells surrounded by lymphocytes in the submucosal fibrous connective tissue, and it was diagnosed as noncaseating granulomatous inflammation. With the tissue specimens from subsequent multiple excisions and several immunohistochemical studies, the diagnoses evolved to benign cellular infiltrate of undetermined origin, epithelioid hemangioma, proliferating endothelial cell neoplasm of uncertain biologic potential, atypical vascular tumor, epithelioid hemangioendothelioma, and kaposiform hemangioendothelioma. We discuss the list of differential diagnoses from various pathologists and propose our diagnosis of epithelioid hemangioendothelioma based on its clinical behavior, histologic features, and immunohistochemical findings.

published proceedings

  • Oral Surg Oral Med Oral Pathol Oral Radiol Endod

author list (cited authors)

  • Cheng, Y., Kessler, H., Rees, T. D., Philofsky, D., & Pontikas, A.

citation count

  • 11

complete list of authors

  • Cheng, Yi-Shing Lisa||Kessler, Harvey||Rees, Terry D||Philofsky, David||Pontikas, Aristidis

publication date

  • June 2006