Gingival swelling in a 13-year-old girl with multiple recurrences. Academic Article

abstract

• We present a challenging case of gingival swelling that recurred several times in 3.5 years in a 13-year-old girl. Histologic evaluation of the initial biopsy revealed groups of epithelioid cells surrounded by lymphocytes in the submucosal fibrous connective tissue, and it was diagnosed as noncaseating granulomatous inflammation. With the tissue specimens from subsequent multiple excisions and several immunohistochemical studies, the diagnoses evolved to benign cellular infiltrate of undetermined origin, epithelioid hemangioma, proliferating endothelial cell neoplasm of uncertain biologic potential, atypical vascular tumor, epithelioid hemangioendothelioma, and kaposiform hemangioendothelioma. We discuss the list of differential diagnoses from various pathologists and propose our diagnosis of epithelioid hemangioendothelioma based on its clinical behavior, histologic features, and immunohistochemical findings.

authors

• Cheng, Yi-Shing

published proceedings

• Oral Surg Oral Med Oral Pathol Oral Radiol Endod

author list (cited authors)

• Cheng, Y., Kessler, H., Rees, T. D., Philofsky, D., & Pontikas, A.

citation count

• 11

complete list of authors

• Cheng, Yi-Shing Lisa||Kessler, Harvey||Rees, Terry D||Philofsky, David||Pontikas, Aristidis

publication date

• January 2007

publisher

• Elsevier  Publisher

published in

• Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology  Journal

keywords

• Adolescent
• Alveolar Process
• Angiolymphoid Hyperplasia With Eosinophilia
• Biomarkers
• Biopsy
• Diagnosis, Differential
• Epithelioid Cells
• Female
• Gingiva
• Gingival Neoplasms
• Hemangioendothelioma, Epithelioid
• Humans
• Neoplasm Recurrence, Local
• Reoperation

Digital Object Identifier (DOI)

• 10.1016/j.tripleo.2005.10.070

start page

• 85

end page

• 91

volume

• 103

issue

• 1

URL

• http://dx.doi.org/10.1016/j.tripleo.2005.10.070