Neonatal Care and Management of Foals Derived by Somatic Cell Nuclear Transfer. Chapter

abstract

• There are few reports on the birth of foals resulting from equine adult somatic cell nuclear transfer (NT). On evaluation of reports of 28 live-born adult somatic-cell NT (clone) foals, 3 died within 2 weeks of birth of complications. Approximately 50 % of all reported cloned foals had complications, some requiring aggressive supportive care. The most common abnormalities reported were neonatal maladjustment syndrome, enlarged umbilical remnant, and angular deformity of the forelimbs, similar to problems described in cloned cattle. In contrast, large offspring syndrome and gross abnormalities of the fetal membranes which are described in cloned cattle are not reported in cloned foals. Reports of the health of foals produced by nuclear transfer suggest that NT foals should be treated aggressively as at-risk foals until all parameters are normal.

authors

• Hinrichs, Katrin

author list (cited authors)

• Johnson, A. K., & Hinrichs, K.

citation count

• 2

complete list of authors

• Johnson, Aime K||Hinrichs, Katrin

Book Title

• Cell Reprogramming

publication date

• January 2015

publisher

• Springer Nature  Publisher

published in

• Methods in molecular biology (Clifton, N.J.)  Journal

keywords

• Angular Limb Deformity
• Animals
• Animals, Newborn
• Clone
• Cloning, Organism
• Disease Management
• Equine
• Foal
• Horse Diseases
• Horses
• Neonatal Maladjustment Syndrome
• Nuclear Transfer
• Nuclear Transfer Techniques
• Postnatal Care
• Umbilical Enlargement

PubMed Central ID

• 26621599

Digital Object Identifier (DOI)

• 10.1007/978-1-4939-2848-4_16

International Standard Book Number (ISBN) 13

• 9781493928477

start page

• 189

end page

• 201

volume

• 1330

URL

• http://dx.doi.org/10.1007/978-1-4939-2848-4_16