Megakaryocytic infection and thrombocytopenia in African swine fever. Academic Article

abstract

• Pigs infected with an African swine fever field isolate of modified virulence became acutely thrombocytopenic four to five days after the onset of fever and viremia. By eight days after inoculation, all pigs were thrombocytopenic. Immunofluorescence microscopy demonstrated that 2 to 10% of the megakaryocytes were infected. By 13 days after inoculation, platelet counts returned to within normal limits, and there was megakaryocytic hyperplasia despite a continued viremia. Secondary complications delayed the return of normal circulating platelet levels in some pigs. The clinical findings of African swine fever are discussed in light of the gross and histologic lesions.

authors

• Edwards, John

published proceedings

• Vet Pathol

author list (cited authors)

• Edwards, J. F., Dodds, W. J., & Slauson, D. O.

citation count

• 20

complete list of authors

• Edwards, JF||Dodds, WJ||Slauson, DO

publication date

• March 1985

publisher

• SAGE Publications  Publisher

published in

• Veterinary Pathology  Journal

keywords

• African Swine Fever
• Animals
• Bone Marrow
• Hyperplasia
• Inclusion Bodies, Viral
• Megakaryocytes
• Microscopy, Fluorescence
• Specific Pathogen-Free Organisms
• Swine
• Thrombocytopenia
• Time Factors
• Viremia

PubMed Central ID

• 3157259

Digital Object Identifier (DOI)

• 10.1177/030098588502200212

start page

• 171

end page

• 176

volume

• 22

issue

• 2

URL

• http://dx.doi.org/10.1177/030098588502200212