Synthesis of collagenase-sensitive polyureas for ligament tissue engineering. Academic Article uri icon


  • Recently, poly(ester urethanes) were investigated for use as ligament grafts due to their exceptional mechanical properties and highly tunable structure; however, these grafts are susceptible to hydrolytic degradation that occurs independent of tissue regeneration. To address this limitation, polyureas containing collagen-derived peptides were synthesized which enable cellular release of proteases to dictate degradation rate. It is hypothesized that this cell-responsive design will facilitate load transfer from the biodegradable scaffold to neotissue at a rate that promotes proper tissue orientation and function while maintaining construct integrity.

published proceedings

  • Macromol Biosci

author list (cited authors)

  • Benhardt, H., Sears, N., Touchet, T., & Cosgriff-Hernandez, E.

citation count

  • 13

complete list of authors

  • Benhardt, Hugh||Sears, Nick||Touchet, Tyler||Cosgriff-Hernandez, Elizabeth

publication date

  • August 2011