Synthesis of collagenase-sensitive polyureas for ligament tissue engineering. Academic Article

abstract

• Recently, poly(ester urethanes) were investigated for use as ligament grafts due to their exceptional mechanical properties and highly tunable structure; however, these grafts are susceptible to hydrolytic degradation that occurs independent of tissue regeneration. To address this limitation, polyureas containing collagen-derived peptides were synthesized which enable cellular release of proteases to dictate degradation rate. It is hypothesized that this cell-responsive design will facilitate load transfer from the biodegradable scaffold to neotissue at a rate that promotes proper tissue orientation and function while maintaining construct integrity.

authors

• Sears, Nicholas

published proceedings

• Macromol Biosci

author list (cited authors)

• Benhardt, H., Sears, N., Touchet, T., & Cosgriff-Hernandez, E.

citation count

• 13

complete list of authors

• Benhardt, Hugh||Sears, Nick||Touchet, Tyler||Cosgriff-Hernandez, Elizabeth

publication date

• August 2011

publisher

• Wiley  Publisher

published in

• Macromolecular Bioscience  Journal

keywords

• Biocompatible Materials
• Collagen
• Collagenases
• Cross-Linking Reagents
• Guided Tissue Regeneration
• Humans
• Ligaments
• Magnetic Resonance Spectroscopy
• Polyethylene Glycols
• Polymers
• Proteolysis
• Tissue Engineering
• Tissue Scaffolds

PubMed Central ID

• 21681959

Digital Object Identifier (DOI)

• 10.1002/mabi.201100063

start page

• 1020

end page

• 1030

volume

• 11

issue

• 8

URL

• http://dx.doi.org/10.1002/mabi.201100063