Overview of current laminitis research. Academic Article

abstract

• All cases of laminitis are characterized by failure of the attachment of the epidermal cells of the epidermal laminae to the underlying basement membrane of the dermal laminae despite the diversity of diseases that underlie the syndrome. The preponderance of evidence supports roles for inflammation, metabolic derangement, endothelial and venous dysfunction, and matrix degradation as causes of laminitis. Inflammation, oxidant stress, and matrix degradation may be factors common to each of these mechanisms that lead to the laminar damage of laminitis. The understanding of the pathophysiology and progression of the disease is incomplete, and this limits efforts to prevent and treat this devastating disease successfully. However, scientific investigations are occurring at a phenomenal rate and shedding light on the pathophysiologic events involved with laminitis.

authors

• Eades, Erma

published proceedings

• Vet Clin North Am Equine Pract

author list (cited authors)

• Eades, S. C.

citation count

• 33

complete list of authors

• Eades, Susan C

publication date

• January 2010

publisher

• Elsevier  Publisher

published in

• Veterinary Clinics of North America: Equine Practice  Journal

keywords

• Animals
• Foot Diseases
• Hoof And Claw
• Horse Diseases
• Horses
• Inflammation
• Research

Digital Object Identifier (DOI)

• 10.1016/j.cveq.2010.01.001

start page

• 51

end page

• 63

volume

• 26

issue

• 1

URL

• http://dx.doi.org/10.1016/j.cveq.2010.01.001