Experimental Models of Laminitis: Starch Overload
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© 2017 by John Wiley & Sons, Inc. Studies conducted during the early 1970s by Harold Garner and coworkers at the University of Missouri established an experimental model for acute sepsis-related laminitis (SRL) accompanied by acute alimentary disease caused by the oral intake of large quantities of digestible carbohydrate. Garner's starch overload model, using a mixture of corn starch and wood flour, provided the first data documenting consistent responses and a course of projection to facilitate the study of laminitis in horses. The preparation of horses for the starch overload model is necessary to improve the consistency of responses. The starch overload (corn starch/wood flour) model of Equine Laminitis appears to more closely mimic clinical cases of laminitis that occur secondary to sepsis-related diseases (e.g., enterocolitis, large intestinal strangulation, septic metritis, pneumonia) than the BWE model of SRL. Starch overload results in enterocolitis caused by overeating soluble carbohydrate, which overwhelms the digestive capability of the small intestine.
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