Evidence for the existence of substance P in the prepubertal rat ovary. II. Immunocytochemical localization. Academic Article uri icon


  • Nerve fibers containing substance P (SP) were localized in ovaries from juvenile and peripubertal rats by immunofluorescence. These fibers were closely associated with the theca externa of antral follicles, as well as being in the interstitial tissue and within the tunica adventitia of small blood vessels, mostly arterioles. Consistently, the greatest amount of SP immunoreactivity was observed surrounding the ovarian vasculature. Substance P was not detected in cells or within the corpora lutea (CL). Additionally, the peripubertal animals seemed to have a greater concentration of ovarian SP than the juvenile animals. Possible functional roles for this peptide in the ovary are discussed.

published proceedings

  • Biol Reprod

author list (cited authors)

  • Dees, W. L., Kozlowski, G. P., Dey, R., & Ojeda, S. R.

citation count

  • 33

complete list of authors

  • Dees, WL||Kozlowski, GP||Dey, R||Ojeda, SR

publication date

  • September 1985