Influence of potassium chloride on alcohol absorption. Academic Article

abstract

• Simultaneous intragastric administration of large doses of KCl (430 mg/kg and 860 mg/kg) with ethanol (4 g/kg) significantly reduces blood alcohol levels and diminishes manifestations of alcohol intoxication in rats. It was shown with parenteral administration of alcohol that the effect is not related to an acceleration of alcohol metabolism. Analysis of alcohol concentrations of gastric and intestinal content as well as in situ studies with animals whose stomachs were ligated at the pylorus revealed that KCl interferes with the absorption of alcohol through inhibition of gastric absorption and gastric emptying. The finding that equimolal concentrations of NaCl were unable to duplicate the described effects characterizes them as specific actions of the potassium ion. 1974.

authors

• Dees, William

published proceedings

• Life Sci

author list (cited authors)

• Redetzki, H. M., Dees, W. L., & Maddox, J. H.

citation count

• 5

complete list of authors

• Redetzki, HM||Dees, WL||Maddox, JH

publication date

• December 1974

publisher

• Elsevier  Publisher

published in

• LIFE SCIENCES  Journal

keywords

• Absorption
• Animals
• Ethanol
• Female
• Gastric Mucosa
• Gastrointestinal Contents
• Intestinal Mucosa
• Intubation, Gastrointestinal
• Potassium Chloride
• Rats
• Rats, Inbred Strains
• Sodium Chloride

PubMed Central ID

• 4621011

Digital Object Identifier (DOI)

• 10.1016/0024-3205(74)90031-9

start page

• 2145

end page

• 2156

volume

• 15

issue

• 12

URL

• http://dx.doi.org/10.1016/0024-3205(74)90031-9