Eicosapentaenoic acid alters vascular reactivity and platelet adhesion in Watanabe heritable hyperlipidemic rabbits.

abstract

• Feeding a diet rich in eicosapentaenoic acid (EPA) to Watanabe heritable hyperlipidemic (WHHL) rabbits resulted in an attenuated aortic contractile response to the vasoconstrictor agent serotonin when compared to responses from WHHL rabbits fed normal rabbit chow. In contrast, only the maximal contractile response to norepinephrine was reduced in EPA-fed rabbit aortas. Additionally, methacholine-induced relaxations were potentiated in aortas obtained from the EPA-fed rabbits. When platelets obtained from EPA-fed rabbits were incubated with arachidonic acid, there was a reduced ability of the platelets to adhere to albumin-coated discs in comparison to control rabbit platelets. These data indicate a potentially beneficial effect of EPA in atherosclerotic WHHL rabbits.

authors

• Clubb, Fred

published proceedings

• Eur J Pharmacol

author list (cited authors)

• Pfister, S. L., Rosolowsky, M., Schmitz, J. M., Clubb, F. J., & Campbell, W. B.

citation count

• 7

complete list of authors

• Pfister, SL||Rosolowsky, M||Schmitz, JM||Clubb, FJ||Campbell, WB

publication date

• January 1989

publisher

• Elsevier  Publisher

published in

• European Journal of Pharmacology  Journal

keywords

• Animals
• Aorta, Thoracic
• Arachidonic Acid
• Arachidonic Acids
• Diet
• Eicosapentaenoic Acid
• Fatty Acids
• Female
• Hemodynamics
• Hyperlipidemias
• In Vitro Techniques
• Male
• Platelet Adhesiveness
• Potassium Chloride
• Rabbits

Digital Object Identifier (DOI)

• 10.1016/0014-2999(89)90183-0

start page

• 85

end page

• 89

volume

• 161

issue

• 1

URL

• http://dx.doi.org/10.1016/0014-2999(89)90183-0