Long- and short-term effects of transmyocardial laser revascularization in acute myocardial ischemia. Academic Article uri icon


  • BACKGROUND AND OBJECTIVE: This study examined the effect of transmyocardial laser revascularization (TMLR) on infarct size and global and regional left ventricular (LV) function. STUDY DESIGN/MATERIALS AND METHODS: Acute ischemia was induced in 24 dogs by ligating the left anterior descending artery. TMLR was done through a left thoracotomy in 12 dogs. The 12 control dogs had ligation only. Global and regional LV function were measured before ligation, then at 6 hours or 3 months after ligation. We calculated the volumetric ratio of damaged myocardium to myocardium at risk (Vd/Vr). RESULTS: At 6 hours, global compensation despite regional dyskinesia was universal; Vd/Vr was the same in control and TMLR dogs. At 3 months, global function during stress was significantly higher in TMLR dogs than in control dogs (P < .05); regional contractions were synergic only in TMLR dogs; mean Vd/Vr was significantly lower in TMLR dogs. CONCLUSION: TMLR limits infarct expansion and improves long-term global and regional function after acute ischemia.

published proceedings

  • Lasers Surg Med

author list (cited authors)

  • Kadipasaoglu, K. A., Pehlivanoglu, S., Conger, J. L., Sasaki, E., de Villalobos, D. H., Cloy, M., ... Frazier, O. H.

citation count

  • 27

complete list of authors

  • Kadipasaoglu, KA||Pehlivanoglu, S||Conger, JL||Sasaki, E||de Villalobos, DH||Cloy, M||Piluiko, V||Clubb, FJ||Cooley, DA||Frazier, OH

publication date

  • March 1997