Surface texturing and coating of biomaterial implants: effects on tissue integration and fibrosis. Academic Article

abstract

• To determine whether texturing and coating have additive effects in promoting tissue integration and inhibiting fibrosis, we evaluated smooth silicone rubber (SSR), textured silicone rubber (TSR), porous silicone rubber (PSR), expanded polytetrafluoroethylene (ePTFE), and porous polyurethane (PPU) subcutaneous implants in eight minipigs. Some of the implants were coated with type IV collagen (Col) and/or fibronectin (Fn). At 6 months, we removed the implants and examined them microscopically. Texturing was more important than Col and Fn in reducing fibrosis and inflammation. The PSR yielded the best response, including reduced fibrosis and inflammation, satisfactory adherence, and no dystrophic mineralization.

authors

• Clubb, Fred

published proceedings

• ASAIO J

altmetric score

• 3

author list (cited authors)

• Clubb, F. J., Clapper, D. L., Deferrari, D. A., Hu, S. P., Seare, W. J., Capek, P. P., ... Parins, S. M.

citation count

• 11

complete list of authors

• Clubb, FJ||Clapper, DL||Deferrari, DA||Hu, SP||Seare, WJ||Capek, PP||Armstrong, J||McGee, MG||Billings, LA||Fuqua, JM||Parins, SM

publication date

• January 1999

publisher

• Wolters Kluwer  Publisher

published in

• ASAIO Journal  Journal

keywords

• Animals
• Biocompatible Materials
• Fibrosis
• Inflammation
• Microscopy
• Prostheses And Implants
• Swine
• Swine, Miniature

Digital Object Identifier (DOI)

• 10.1097/00002480-199907000-00006

start page

• 281

end page

• 287

volume

• 45

issue

• 4

URL

• http://dx.doi.org/10.1097/00002480-199907000-00006