Surface texturing and coating of biomaterial implants: effects on tissue integration and fibrosis. Academic Article uri icon


  • To determine whether texturing and coating have additive effects in promoting tissue integration and inhibiting fibrosis, we evaluated smooth silicone rubber (SSR), textured silicone rubber (TSR), porous silicone rubber (PSR), expanded polytetrafluoroethylene (ePTFE), and porous polyurethane (PPU) subcutaneous implants in eight minipigs. Some of the implants were coated with type IV collagen (Col) and/or fibronectin (Fn). At 6 months, we removed the implants and examined them microscopically. Texturing was more important than Col and Fn in reducing fibrosis and inflammation. The PSR yielded the best response, including reduced fibrosis and inflammation, satisfactory adherence, and no dystrophic mineralization.

published proceedings


altmetric score

  • 3

author list (cited authors)

  • Clubb, F. J., Clapper, D. L., Deferrari, D. A., Hu, S. P., Seare, W. J., Capek, P. P., ... Parins, S. M.

citation count

  • 11

complete list of authors

  • Clubb, FJ||Clapper, DL||Deferrari, DA||Hu, SP||Seare, WJ||Capek, PP||Armstrong, J||McGee, MG||Billings, LA||Fuqua, JM||Parins, SM

publication date

  • January 1999