Genomic and experimental evidence for a potential sexual cycle in the pathogenic thermal dimorphic fungus Penicillium marneffei. Academic Article

abstract

• All meiotic genes (except HOP1) and genes encoding putative pheromone processing enzymes, pheromone receptors and pheromone response pathways proteins in Aspergillus fumigatus and Aspergillus nidulans and a putative MAT-1 alpha box mating-type gene were present in the Penicillium marneffei genome. A putative MAT-2 high-mobility group mating-type gene was amplified from a MAT-1 alpha box mating-type gene-negative P. marneffei strain. Among 37 P. marneffei patient strains, MAT-1 alpha box and MAT-2 high-mobility group mating-type genes were present in 23 and 14 isolates, respectively. We speculate that P. marneffei can potentially be a heterothallic fungus that does not switch mating type.

authors

• Cai, James

published proceedings

• FEBS Lett

altmetric score

• 1

author list (cited authors)

• Woo, P., Chong, K., Tse, H., Cai, J. J., Lau, C., Zhou, A. C., Lau, S., & Yuen, K.

citation count

• 56

complete list of authors

• Woo, Patrick CY||Chong, Ken TK||Tse, Herman||Cai, James J||Lau, Candy CY||Zhou, Anna C||Lau, Susanna KP||Yuen, Kwok-yung

publication date

• June 2006

publisher

• Wiley  Publisher

published in

• FEBS Letters  Journal

keywords

• Amino Acid Sequence
• Base Sequence
• DNA Primers
• Genome, Fungal
• Mating Factor
• Molecular Sequence Data
• Penicillium
• Peptides
• Phylogeny
• Polymerase Chain Reaction
• Sequence Homology, Amino Acid

PubMed Central ID

• 16714021

Digital Object Identifier (DOI)

• 10.1016/j.febslet.2006.05.014

start page

• 3409

end page

• 3416

volume

• 580

issue

• 14

URL

• http://dx.doi.org/10.1016/j.febslet.2006.05.014