Genomic and experimental evidence for a potential sexual cycle in the pathogenic thermal dimorphic fungus Penicillium marneffei. Academic Article uri icon


  • All meiotic genes (except HOP1) and genes encoding putative pheromone processing enzymes, pheromone receptors and pheromone response pathways proteins in Aspergillus fumigatus and Aspergillus nidulans and a putative MAT-1 alpha box mating-type gene were present in the Penicillium marneffei genome. A putative MAT-2 high-mobility group mating-type gene was amplified from a MAT-1 alpha box mating-type gene-negative P. marneffei strain. Among 37 P. marneffei patient strains, MAT-1 alpha box and MAT-2 high-mobility group mating-type genes were present in 23 and 14 isolates, respectively. We speculate that P. marneffei can potentially be a heterothallic fungus that does not switch mating type.

published proceedings

  • FEBS Lett

altmetric score

  • 1

author list (cited authors)

  • Woo, P., Chong, K., Tse, H., Cai, J. J., Lau, C., Zhou, A. C., Lau, S., & Yuen, K.

citation count

  • 56

complete list of authors

  • Woo, Patrick CY||Chong, Ken TK||Tse, Herman||Cai, James J||Lau, Candy CY||Zhou, Anna C||Lau, Susanna KP||Yuen, Kwok-yung

publication date

  • June 2006