Multicentric squamous cell carcinoma in situ associated with papillomavirus in a ferret. Academic Article

abstract

• A 6-year-old castrated male ferret presented with multiple black and tan proliferative skin lesions. Histologically, the lesions were characterized by multifocal plaques of irregular epidermal hyperplasia and full-thickness dysplasia, with loss of normal epithelial stratification, loss of nuclear polarity, and rare eosinophilic intranuclear inclusion bodies in the superficial layers of the epidermis. Immunohistochemical staining with a monoclonal antibody against papillomaviruses was strongly immunoreactive. Ultrastructurally, large numbers of hexagonal viral particles approximately 50 nm were observed within the nuclei of dysplastic superficial keratinocytes. To the authors' knowledge, this is the first report of a ferret multicentric squamous cell carcinoma in situ associated with papillomavirus.

authors

• Mansell, Karen

published proceedings

• Vet Pathol

altmetric score

• 0.5

author list (cited authors)

• Rodrigues, A., Gates, L., Payne, H. R., Kiupel, M., & Mansell, J.

citation count

• 18

complete list of authors

• Rodrigues, A||Gates, L||Payne, HR||Kiupel, M||Mansell, J

publication date

• September 2010

publisher

• SAGE Publications  Publisher

published in

• Veterinary Pathology  Journal

keywords

• Animals
• Carcinoma, Squamous Cell
• DNA, Viral
• Fatal Outcome
• Ferrets
• Immunohistochemistry
• Male
• Microscopy, Electron, Transmission
• Papillomaviridae
• Papillomavirus Infections
• Polymerase Chain Reaction
• Skin Neoplasms

PubMed Central ID

• 20466863

Digital Object Identifier (DOI)

• 10.1177/0300985810369899

start page

• 964

end page

• 968

volume

• 47

issue

• 5

URL

• http://dx.doi.org/10.1177/0300985810369899